Exogenous expression of a dominant negative ROR 1 vector in muscle cells impairs differentiation: ROR 1 directly interacts with p300 and MyoD
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Exogenous expression of a dominant negative RORα1 vector in muscle cells impairs differentiation: RORα1 directly interacts with p300 and MyoD
ROR/RZR is an orphan nuclear receptor that has no known ligand in the ‘classical sense’. In the present study we demonstrate that RORα is constitutively expressed during the differentiation of proliferating myoblasts to post-mitotic multinucleated myotubes, that have acquired a contractile phenotype. Exogenous expression of dominant negative RORα1∆E mRNA in myogenic cells significantly reduces ...
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IL-17–producing CD4 + Th17 cells, CD8 + Tc17 cells, and gd T cells play critical roles in the pathogenesis of autoimmune psoriasis. RORgt is required for the differentiation of Th17 cells and expression of IL-17. In this article, we describe a novel, potent, and selective RORgt inverse agonist (TMP778), and its inactive diastereomer (TMP776). This chemistry, for the first time to our knowledge,...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1999
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/27.2.411